Skeletal muscle fibrosis is a major pathological hallmark of chronic myopathies in which
myofibers are replaced by progressive deposition of collagen and other extracellular matrix
proteins produced by muscle fibroblasts. Recent studies have shown that in the absence of
the endogenous muscle growth regulator myostatin, regeneration of muscle is enhanced,
and muscle fibrosis is correspondingly reduced. We now demonstrate that myostatin not
only regulates the growth of myocytes but also directly regulates muscle fibroblasts. Our …