[HTML][HTML] Specificity and structure of a high affinity activin receptor-like kinase 1 (ALK1) signaling complex
SA Townson, E Martinez-Hackert, C Greppi… - Journal of Biological …, 2012 - ASBMB
Activin receptor-like kinase 1 (ALK1), an endothelial cell-specific type I receptor of the TGF-β
superfamily, is an important regulator of normal blood vessel development as well as
pathological tumor angiogenesis. As such, ALK1 is an important therapeutic target. Thus,
several ALK1-directed agents are currently in clinical trials as anti-angiogenic cancer
therapeutics. Given the biological and clinical importance of the ALK1 signaling pathway, we
sought to elucidate the biophysical and structural basis underlying ALK1 signaling. The TGF …
superfamily, is an important regulator of normal blood vessel development as well as
pathological tumor angiogenesis. As such, ALK1 is an important therapeutic target. Thus,
several ALK1-directed agents are currently in clinical trials as anti-angiogenic cancer
therapeutics. Given the biological and clinical importance of the ALK1 signaling pathway, we
sought to elucidate the biophysical and structural basis underlying ALK1 signaling. The TGF …