[HTML][HTML] Metabolic deficiencies in alcohol dehydrogenase Adh1, Adh3, and Adh4 null mutant mice: Overlapping roles of Adh1 and Adh4 in ethanol clearance and …
L Deltour, MH Foglio, G Duester - Journal of Biological Chemistry, 1999 - ASBMB
Targeting of mouse alcohol dehydrogenase genesAdh1, Adh3, and Adh4 resulted in null
mutant mice that all developed and reproduced apparently normally but differed markedly in
clearance of ethanol and formaldehyde plus metabolism of retinol to the signaling molecule
retinoic acid. Following administration of an intoxicating dose of ethanol, Adh1−/− mice, and
to a lesser extent Adh4−/− mice, but not Adh3−/− mice, displayed significant reductions in
blood ethanol clearance. Ethanol-induced sleep was significantly longer only in Adh1 …
mutant mice that all developed and reproduced apparently normally but differed markedly in
clearance of ethanol and formaldehyde plus metabolism of retinol to the signaling molecule
retinoic acid. Following administration of an intoxicating dose of ethanol, Adh1−/− mice, and
to a lesser extent Adh4−/− mice, but not Adh3−/− mice, displayed significant reductions in
blood ethanol clearance. Ethanol-induced sleep was significantly longer only in Adh1 …