Exact prediction of a natural T cell epitope
O Rötzschke, K Falk, S Stevanovic… - European journal of …, 1991 - Wiley Online Library
European journal of immunology, 1991•Wiley Online Library
T lymphocytes recognize their antigen as peptides associated with major histocompatibility
complex (MHC) molecules. Peptides naturally presented by MHC class I molecules are
uniform in length and have a specific motif, both defined by the respective MHCallele (Falk,
K. et al. Nature 1991.351: 290). These allele-specific motifs should allow exact prediction of
natural T cell epitopes. H-2Kb-restricted epitopes, for example, have a length of eight amino
acid residues and conserved anchor residues at positions 5 and 8. According to this …
complex (MHC) molecules. Peptides naturally presented by MHC class I molecules are
uniform in length and have a specific motif, both defined by the respective MHCallele (Falk,
K. et al. Nature 1991.351: 290). These allele-specific motifs should allow exact prediction of
natural T cell epitopes. H-2Kb-restricted epitopes, for example, have a length of eight amino
acid residues and conserved anchor residues at positions 5 and 8. According to this …
T lymphocytes recognize their antigen as peptides associated with major histocompatibility complex (MHC) molecules. Peptides naturally presented by MHC class I molecules are uniform in length and have a specific motif, both defined by the respective MHCallele (Falk, K. et al. Nature 1991.351: 290). These allele-specific motifs should allow exact prediction of natural T cell epitopes. H-2Kb-restricted epitopes, for example, have a length of eight amino acid residues and conserved anchor residues at positions 5 and 8. According to this information, we predicted the natural Kb-restricted epitope of ovalbumin, thought to be contained in the 19-mer IINFEKLTEWTSSNVMEER, to be SIINFEKL. Here we show that this prediction is correct. Thus, exact prediction of natural Tcell epitopes is possible.
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