Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

LV Sinclair, J Rolf, E Emslie, YB Shi, PM Taylor… - Nature …, 2013 - nature.com
LV Sinclair, J Rolf, E Emslie, YB Shi, PM Taylor, DA Cantrell
Nature immunology, 2013nature.com
T lymphocytes must regulate nutrient uptake to meet the metabolic demands of an immune
response. Here we show that the intracellular supply of large neutral amino acids (LNAAs) in
T cells was regulated by pathogens and the T cell antigen receptor (TCR). T cells responded
to antigen by upregulating expression of many amino-acid transporters, but a single System
L ('leucine-preferring system') transporter, Slc7a5, mediated uptake of LNAAs in activated T
cells. Slc7a5-null T cells were unable to metabolically reprogram in response to antigen and …
Abstract
T lymphocytes must regulate nutrient uptake to meet the metabolic demands of an immune response. Here we show that the intracellular supply of large neutral amino acids (LNAAs) in T cells was regulated by pathogens and the T cell antigen receptor (TCR). T cells responded to antigen by upregulating expression of many amino-acid transporters, but a single System L ('leucine-preferring system') transporter, Slc7a5, mediated uptake of LNAAs in activated T cells. Slc7a5-null T cells were unable to metabolically reprogram in response to antigen and did not undergo clonal expansion or effector differentiation. The metabolic catastrophe caused by loss of Slc7a5 reflected the requirement for sustained uptake of the LNAA leucine for activation of the serine-threonine kinase complex mTORC1 and for expression of the transcription factor c-Myc. Control of expression of the System L transporter by pathogens is thus a critical metabolic checkpoint for T cells.
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