[HTML][HTML] Caveolin-deficient mice: insights into caveolar function human disease

B Razani, MP Lisanti - The Journal of clinical investigation, 2001 - Am Soc Clin Investig
The Journal of clinical investigation, 2001Am Soc Clin Investig
We and others have recently reported the generation of mice with a targeted disruption of
the caveolin-1 (Cav1) locus (8, 9). Here, we will consider several of the pivotal observations
made in these mice which have expanded our understanding of caveolar function (see
Table 1 for a summary). Perhaps the biggest initial surprise in the characterization of these
mice was the realization that loss of a major cellular organelle imparts no developmental
abnormality or lethality. In fact, cursory examination of the mice into adulthood and beyond …
We and others have recently reported the generation of mice with a targeted disruption of the caveolin-1 (Cav1) locus (8, 9). Here, we will consider several of the pivotal observations made in these mice which have expanded our understanding of caveolar function (see Table 1 for a summary). Perhaps the biggest initial surprise in the characterization of these mice was the realization that loss of a major cellular organelle imparts no developmental abnormality or lethality. In fact, cursory examination of the mice into adulthood and beyond reveals no overt phenotypic abnormalities, except for a tendency to remain smaller than their wild-type counterparts (8).
The Journal of Clinical Investigation