Clinical effects of long-term metreleptin treatment in patients with lipodystrophy
JL Chan, K Lutz, E Cochran, W Huang, Y Peters… - Endocrine Practice, 2011 - Elsevier
Objective To evaluate the long-term clinical effect of treatment with metreleptin (an analogue
of human leptin) on glycemic and lipid abnormalities and markers of hepatic steatosis in
patients with inherited or acquired lipodystrophy. Methods Fifty-five patients (36 with
generalized lipodystrophy and 19 with partial lipodystrophy) with at least 1 of 3 metabolic
abnormalities (diabetes mellitus, fasting triglyceride level≥ 200 mg/dL, and insulin
resistance) and low leptin levels received subcutaneous injections of metreleptin once or …
of human leptin) on glycemic and lipid abnormalities and markers of hepatic steatosis in
patients with inherited or acquired lipodystrophy. Methods Fifty-five patients (36 with
generalized lipodystrophy and 19 with partial lipodystrophy) with at least 1 of 3 metabolic
abnormalities (diabetes mellitus, fasting triglyceride level≥ 200 mg/dL, and insulin
resistance) and low leptin levels received subcutaneous injections of metreleptin once or …