Nucleotides mediate intercellular communication by activating purinergic receptors and take
part in various physiological and pathological processes. Abnormal purinergic signaling
plays important roles in malignant progression. P2X7, which belongs to the P2X family of
purinergic receptors, is abnormally expressed in various types of malignancies including
leukemia. However, its role and molecular mechanism of action in leukemia have not been
elucidated. Here, we analyzed the correlation between P2X7 expression and clinical …

Epigenetic regulations play crucial roles in leukemogenesis and leukemia progression.
SUV39H1 is the dominant H3K9 methyltransferase in the hematopoietic system, and its
expression declines with aging. However, the role of SUV39H1 via its-mediated repressive
modification H3K9me3 in leukemogenesis/leukemia progression remains to be explored.
We found that SUV39H1 was down-regulated in a variety of leukemias, including MLL-r
AML, as compared with normal individuals. Decreased levels of Suv39h1 expression and …