Expression of P2X7 in human hematopoietic cell lines and leukemia patients

XJ Zhang, GG Zheng, XT Ma, YH Yang, G Li, Q Rao… - Leukemia research, 2004 - Elsevier
The P2X7 nucleotide receptor is an adenosine 5′-triphosphate (ATP)-gated ion channel,
which is widely expressed in cells of hematopoietic origin and functions as a non-selective
cation channel permeable to Na+, Ca2+, etc upon stimulation. Here, we investigated P2X7
expression in 11 human hematopoietic cell lines, representing different lineages, as well as
bone marrow mononuclear cells (BMMC) samples from 87 leukemia and 10 myelodysplastic
syndrome (MDS) patients. Semi-quantitative reverse transcription polymerase chain reaction …