[HTML][HTML] The C terminus of tubulin, a versatile partner for cationic molecules: binding of Tau, polyamines, and calcium
J Lefèvre, KG Chernov, V Joshi, S Delga… - Journal of biological …, 2011 - ASBMB
The C-terminal region of tubulin is involved in multiple aspects of the regulation of
microtubule assembly. To elucidate the molecular mechanisms of this regulation, we study
here, using different approaches, the interaction of Tau, spermine, and calcium, three
representative partners of the tubulin C-terminal region, with a peptide composed of the last
42 residues of α1a-tubulin. The results show that their binding involves overlapping amino
acid stretches in the C-terminal tubulin region: amino acid residues 421–441 for Tau, 430 …
microtubule assembly. To elucidate the molecular mechanisms of this regulation, we study
here, using different approaches, the interaction of Tau, spermine, and calcium, three
representative partners of the tubulin C-terminal region, with a peptide composed of the last
42 residues of α1a-tubulin. The results show that their binding involves overlapping amino
acid stretches in the C-terminal tubulin region: amino acid residues 421–441 for Tau, 430 …