[HTML][HTML] A three-dimensional homology model of lipid-free apolipoprotein A-IV using cross-linking and mass spectrometry
Human apolipoprotein A-IV (apoA-IV) is a 46-kDa exchangeable plasma protein with many
proposed functions. It is involved in chylomicron assembly and secretion, protection from
atherosclerosis through a variety of mechanisms, and inhibition of food intake. There is little
structural basis for these proposed functions due to the lack of a solved three-dimensional
structure of the protein by x-ray crystallography or NMR. Based on previous studies, we
hypothesized that lipid-free apoA-IV exists in a helical bundle, like other apolipoprotein …
proposed functions. It is involved in chylomicron assembly and secretion, protection from
atherosclerosis through a variety of mechanisms, and inhibition of food intake. There is little
structural basis for these proposed functions due to the lack of a solved three-dimensional
structure of the protein by x-ray crystallography or NMR. Based on previous studies, we
hypothesized that lipid-free apoA-IV exists in a helical bundle, like other apolipoprotein …