Testosterone treatment and cognitive function in older men with low testosterone and age-associated memory impairment

SM Resnick, AM Matsumoto, AJ Stephens-Shields… - Jama, 2017 - jamanetwork.com
Importance Most cognitive functions decline with age. Prior studies suggest that testosterone
treatment may improve these functions. Objective To determine if testosterone treatment
compared with placebo is associated with improved verbal memory and other cognitive
functions in older men with low testosterone and age-associated memory impairment
(AAMI). Design, Setting, and Participants The Testosterone Trials (TTrials) were 7 trials to
assess the efficacy of testosterone treatment in older men with low testosterone levels. The …