[CITATION][C] Detection of prostate cancer following gender reassignment
CN Molokwu, JS Appelbaum, RA Miksad - BJU international, 2008 - Wiley Online Library
CN Molokwu, JS Appelbaum, RA Miksad
BJU international, 2008•Wiley Online LibraryThe authors imply that the lack of an association between the 3-month time point and
survival after cystectomy is an indication of the fact that use of neoadjuvant chemotherapy in
these patients might pose no significant additional risk due to the necessary delay in time to
cystectomy. However, the response rates to neoadjuvant chemotherapy are far from 100%
and some of the patients not responding will inevitably progress during their neoadjuvant
chemotherapy. Lastly, TUR is one of the interim steps before a patient (particularly one with …
survival after cystectomy is an indication of the fact that use of neoadjuvant chemotherapy in
these patients might pose no significant additional risk due to the necessary delay in time to
cystectomy. However, the response rates to neoadjuvant chemotherapy are far from 100%
and some of the patients not responding will inevitably progress during their neoadjuvant
chemotherapy. Lastly, TUR is one of the interim steps before a patient (particularly one with …
The authors imply that the lack of an association between the 3-month time point and survival after cystectomy is an indication of the fact that use of neoadjuvant chemotherapy in these patients might pose no significant additional risk due to the necessary delay in time to cystectomy. However, the response rates to neoadjuvant chemotherapy are far from 100% and some of the patients not responding will inevitably progress during their neoadjuvant chemotherapy.
Lastly, TUR is one of the interim steps before a patient (particularly one with clinically muscle-invasive disease) proceeds to cystectomy. These data do not address the relevance of the interval from symptom presentation to TUR or cystectomy, which might be a more relevant variable and can also be clearly influenced by patient and physician education. One must also consider other consequences of treatment delay [2], such as psychological impact, which is arguably a ‘softer’endpoint.
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