Association of menopausal hormone therapy with breast cancer incidence and mortality during long-term follow-up of the women's health initiative randomized clinical …
RT Chlebowski, GL Anderson, AK Aragaki… - Jama, 2020 - jamanetwork.com
Importance The influence of menopausal hormone therapy on breast cancer remains
unsettled with discordant findings from observational studies and randomized clinical trials.
Objective To assess the association of prior randomized use of estrogen plus progestin or
prior randomized use of estrogen alone with breast cancer incidence and mortality in the
Women's Health Initiative clinical trials. Design, Setting, and Participants Long-term follow-
up of 2 placebo-controlled randomized clinical trials that involved 27 347 postmenopausal …
unsettled with discordant findings from observational studies and randomized clinical trials.
Objective To assess the association of prior randomized use of estrogen plus progestin or
prior randomized use of estrogen alone with breast cancer incidence and mortality in the
Women's Health Initiative clinical trials. Design, Setting, and Participants Long-term follow-
up of 2 placebo-controlled randomized clinical trials that involved 27 347 postmenopausal …