Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women's Health Initiative randomized trials

JAE Manson, RT Chlebowski, ML Stefanick… - Jama, 2013 - jamanetwork.com
Importance Menopausal hormone therapy continues in clinical use but questions remain
regarding its risks and benefits for chronic disease prevention. Objective To report a
comprehensive, integrated overview of findings from the 2 Women's Health Initiative (WHI)
hormone therapy trials with extended postintervention follow-up. Design, Setting, and
Participants A total of 27 347 postmenopausal women aged 50 to 79 years were enrolled at
40 US centers. Interventions Women with an intact uterus received conjugated equine …