Hepatocyte γ-catenin compensates for conditionally deleted β-catenin at adherens junctions
ED Wickline, PK Awuah, J Behari, M Ross, DB Stolz… - Journal of …, 2011 - Elsevier
BACKGROUND & AIMS: Wnt/β-catenin signaling is important in liver physiology. Moreover,
β-catenin is also pivotal in adherens junctions (AJ). Here, we investigate hepatocyte-specific
β-catenin conditional null mice (KO) for any alterations in AJ and related tight junctions (TJ).
METHODS: Using gene array, PCR, Western blot, immunohistochemistry,
immunofluorescence, and co-immunoprecipitation, we compare and contrast the
composition of AJ and TJ in KO and littermate wild-type (WT) control livers. RESULTS: We …
β-catenin is also pivotal in adherens junctions (AJ). Here, we investigate hepatocyte-specific
β-catenin conditional null mice (KO) for any alterations in AJ and related tight junctions (TJ).
METHODS: Using gene array, PCR, Western blot, immunohistochemistry,
immunofluorescence, and co-immunoprecipitation, we compare and contrast the
composition of AJ and TJ in KO and littermate wild-type (WT) control livers. RESULTS: We …