CXCL10 expressing hematopoietic-derived cells are requisite in defense against HSV-1 infection in the nervous system of CXCL10 deficient mice
TR Wuest, M Thapa, M Zheng, DJJ Carr - Journal of neuroimmunology, 2011 - Elsevier
The chemokine CXCL10 is crucial for the control of viral replication through the regulation of
mobilization of antigen-specific T cells to sites of infection. CXCL10 is highly expressed both
at sites of inflammation as well as constitutively within lymphoid organs by both bone
marrow (BM)-derived and non-BM-derived cells. However, the relative immunologic
importance of CXCL10 expressed by these divergent sources relative to HSV-1 infection is
unknown. Using mouse chimeras reconstituted with either wild type or CXCL10 deficient …
mobilization of antigen-specific T cells to sites of infection. CXCL10 is highly expressed both
at sites of inflammation as well as constitutively within lymphoid organs by both bone
marrow (BM)-derived and non-BM-derived cells. However, the relative immunologic
importance of CXCL10 expressed by these divergent sources relative to HSV-1 infection is
unknown. Using mouse chimeras reconstituted with either wild type or CXCL10 deficient …