Interleukin-17 and type 17 helper T cells

P Miossec, T Korn, VK Kuchroo - New England Journal of …, 2009 - Mass Medical Soc
P Miossec, T Korn, VK Kuchroo
New England Journal of Medicine, 2009Mass Medical Soc
Type 17 helper T cells (Th17)—a third class of T cells—and their major cytokine, interleukin-
17, are essential for the defense against certain fungi, extracellular bacteria, and
Mycobacterium tuberculosis. Defective control of Th17 cells and production of interleukin-17
are prominent in chronic inflammation and several immunoinflammatory disorders.
Monoclonal antibodies against cytokines produced by Th17 cells are being investigated in
clinical trials.
Type 17 helper T cells (Th17) — a third class of T cells — and their major cytokine, interleukin-17, are essential for the defense against certain fungi, extracellular bacteria, and Mycobacterium tuberculosis. Defective control of Th17 cells and production of interleukin-17 are prominent in chronic inflammation and several immunoinflammatory disorders. Monoclonal antibodies against cytokines produced by Th17 cells are being investigated in clinical trials.
The New England Journal Of Medicine