Antimicrobial peptide response to group B Streptococcus in human extraplacental membranes in culture
E Boldenow, S Jones, RW Lieberman, MC Chames… - Placenta, 2013 - Elsevier
OBJECTIVE: Streptococcus agalactiae (GBS) is an important cause of chorioamnionitis. This
study characterizes GBS colonization and stimulation of antimicrobial responses in human
extraplacental membranes using an ex vivo transwell two-compartment system of full-
thickness membranes and live GBS. STUDY DESIGN: Human extraplacental membranes
were affixed to transwell frames (without synthetic membranes). Live GBS was added to the
decidual side of membranes in transwell cultures, and cocultures were incubated for 4, 8 …
study characterizes GBS colonization and stimulation of antimicrobial responses in human
extraplacental membranes using an ex vivo transwell two-compartment system of full-
thickness membranes and live GBS. STUDY DESIGN: Human extraplacental membranes
were affixed to transwell frames (without synthetic membranes). Live GBS was added to the
decidual side of membranes in transwell cultures, and cocultures were incubated for 4, 8 …