[HTML][HTML] The signal peptide of the IgE receptor α-chain prevents surface expression of an immunoreceptor tyrosine-based activation motif-free receptor pool
B Platzer, E Fiebiger - Journal of biological chemistry, 2010 - ASBMB
The high affinity receptor for IgE, Fc epsilon receptor I (FcϵRI), is an activating immune
receptor and key regulator of allergy. Antigen-mediated cross-linking of IgE-loaded FcϵRI α-
chains induces cell activation via immunoreceptor tyrosine-based activation motifs in
associated signaling subunits, such as FcϵRI γ-chains. Here we show that the human FcϵRI
α-chain can efficiently reach the cell surface by itself as an IgE-binding receptor in the
absence of associated signaling subunits when the endogenous signal peptide is swapped …
receptor and key regulator of allergy. Antigen-mediated cross-linking of IgE-loaded FcϵRI α-
chains induces cell activation via immunoreceptor tyrosine-based activation motifs in
associated signaling subunits, such as FcϵRI γ-chains. Here we show that the human FcϵRI
α-chain can efficiently reach the cell surface by itself as an IgE-binding receptor in the
absence of associated signaling subunits when the endogenous signal peptide is swapped …