Modification of cellular and humoral immunity by somatically reverted T cells in X-linked lymphoproliferative syndrome type 1
LETTERS TO THE EDITOR 421 (see Fig E1 in this article's Online Repository at www.
jacionline. org) at age 6 years and hypogammaglobulinemia, and the other (P25. 3) is a 37-
year-old man with IgG3 and IgG4 deficiency. Although P25. 2 died because of sepsis at age
39 years, P25. 1 and P25. 3 remain relative healthy. Whole-exome sequencing of P25. 1
and P25. 3 revealed the SH2D1A mutation (c. 2T> C, p. Met1Thr). P25. 2 also had the same
mutation and the mother of P25. 1 (M25. 1) had a heterozygous allele, indicating a carrier …
jacionline. org) at age 6 years and hypogammaglobulinemia, and the other (P25. 3) is a 37-
year-old man with IgG3 and IgG4 deficiency. Although P25. 2 died because of sepsis at age
39 years, P25. 1 and P25. 3 remain relative healthy. Whole-exome sequencing of P25. 1
and P25. 3 revealed the SH2D1A mutation (c. 2T> C, p. Met1Thr). P25. 2 also had the same
mutation and the mother of P25. 1 (M25. 1) had a heterozygous allele, indicating a carrier …