[HTML][HTML] CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells

H Yamaguchi, HG Wang - Journal of Biological Chemistry, 2004 - ASBMB
It has been shown that excess stress to the endoplasmic reticulum (ER) triggers apoptosis,
but the mechanisms underlying these processes remain unclear. We and others have
reported previously that DR5 expression is up-regulated in thapsigargin (THG)-treated
human cancer cells. Here, we provide evidence that CHOP is involved in THG up-regulation
of DR5, which is a critical step for ER stress-induced apoptosis in human cancer cells. In
human colon cancer HCT116 cells, knockdown of DR5 by siRNA blocked THG-induced Bax …