Neutrophils exacerbate tuberculosis infection in genetically susceptible mice
V Yeremeev, I Linge, T Kondratieva, A Apt - Tuberculosis, 2015 - Elsevier
Mice of the I/St inbred strain genetically hyper-susceptible to TB infection and prone to form
neutrophil-abundant necrotic lung lesions and relatively resistant mice of the C57BL/6 (B6)
strain were infected with 100 CFU of M. tuberculosis H37Rv. To verify the role of neutrophils
in TB immunity, we selectively depleted neutrophils from infected mice with highly specific
1A8 anti-Ly6G antibodies at day 2 and 6 post-challenge. Depletion of neutrophils resulted in
reduced lung tissue pathology, mycobacterial CFU counts and an increase of the survival …
neutrophil-abundant necrotic lung lesions and relatively resistant mice of the C57BL/6 (B6)
strain were infected with 100 CFU of M. tuberculosis H37Rv. To verify the role of neutrophils
in TB immunity, we selectively depleted neutrophils from infected mice with highly specific
1A8 anti-Ly6G antibodies at day 2 and 6 post-challenge. Depletion of neutrophils resulted in
reduced lung tissue pathology, mycobacterial CFU counts and an increase of the survival …