[HTML][HTML] Identification of antibody targets for tuberculosis serology using high-density nucleic acid programmable protein arrays
Better and more diverse biomarkers for the development of simple point-of-care tests for
active tuberculosis (TB), a clinically heterogeneous disease, are urgently needed. We
generated a proteomic Mycobacterium tuberculosis (Mtb) High-Density Nucleic Acid
Programmable Protein Array (HD-NAPPA) that used a novel multiplexed strategy for
expedited high-throughput screening for antibody responses to the Mtb proteome. We
screened sera from HIV uninfected and coinfected TB patients and controls (n= 120) from …
active tuberculosis (TB), a clinically heterogeneous disease, are urgently needed. We
generated a proteomic Mycobacterium tuberculosis (Mtb) High-Density Nucleic Acid
Programmable Protein Array (HD-NAPPA) that used a novel multiplexed strategy for
expedited high-throughput screening for antibody responses to the Mtb proteome. We
screened sera from HIV uninfected and coinfected TB patients and controls (n= 120) from …