Propranolol stops progressive multiple cerebral cavernoma in an adult patient
M Reinhard, F Schuchardt, S Meckel, J Heinz… - Journal of the …, 2016 - Elsevier
Objective To report a case of a patient with multiple cerebral cavernous malformations
(CCM). Observation A 22 year old man with mild von Willebrand disease presented with two
occipital CCM, one of them with acute hemorrhage. Genetic testing for CCM1–3 did not
reveal a mutation. Over a period of 54 months, the patient suffered 26 new CCM
hemorrhages despite multiple treatment attempts including thalidomide, simvastatin and
hemostatic factors. Only after initiation of propranolol, which has already been successfully …
(CCM). Observation A 22 year old man with mild von Willebrand disease presented with two
occipital CCM, one of them with acute hemorrhage. Genetic testing for CCM1–3 did not
reveal a mutation. Over a period of 54 months, the patient suffered 26 new CCM
hemorrhages despite multiple treatment attempts including thalidomide, simvastatin and
hemostatic factors. Only after initiation of propranolol, which has already been successfully …