Intravenous labeling and analysis of the content of thymic perivascular spaces
R Ruscher, KA Hogquist - Bio-protocol, 2018 - bio-protocol.org
Following development in the thymus, T cells are thought to exit into the periphery
predominantly through perivascular spaces (PVS). This exit route is used by conventional T
cells, and likely also applies to unconventional T cell subsets, such as precursors of CD8αα
and TCRγδ intraepithelial lymphocytes, regulatory T cells and natural killer T cells.
Additional cell types might also be found in the PVS and initiate interactions with exiting T
cells. The exact content of the PVS, and the processes within, are not well studied. To …
predominantly through perivascular spaces (PVS). This exit route is used by conventional T
cells, and likely also applies to unconventional T cell subsets, such as precursors of CD8αα
and TCRγδ intraepithelial lymphocytes, regulatory T cells and natural killer T cells.
Additional cell types might also be found in the PVS and initiate interactions with exiting T
cells. The exact content of the PVS, and the processes within, are not well studied. To …