[HTML][HTML] HLA mismatching favoring host-versus-graft NK cell activity via KIR3DL1 is associated with improved outcomes following lung transplantation
JR Greenland, H Sun, D Calabrese, T Chong… - American Journal of …, 2017 - Elsevier
Chronic lung allograft dysfunction (CLAD) is linked to rejection and limits survival following
lung transplantation. HLA-Bw4 recipients of HLA-Bw6 grafts have enhanced host-versus-
graft (HVG) natural killer (NK) cell activity mediated by killer cell immunoglobulin-like
receptor (KIR) 3DL1 ligand. Because NK cells may promote tolerance by depleting antigen-
presenting cells, we hypothesized improved outcomes for HLA-Bw4 recipients of HLA-Bw6
grafts. We evaluated differences in acute cellular rejection and CLAD-free survival across …
lung transplantation. HLA-Bw4 recipients of HLA-Bw6 grafts have enhanced host-versus-
graft (HVG) natural killer (NK) cell activity mediated by killer cell immunoglobulin-like
receptor (KIR) 3DL1 ligand. Because NK cells may promote tolerance by depleting antigen-
presenting cells, we hypothesized improved outcomes for HLA-Bw4 recipients of HLA-Bw6
grafts. We evaluated differences in acute cellular rejection and CLAD-free survival across …