Pre-existing self-reactive IgA antibodies associated with primary graft dysfunction after lung transplantation
V Kaza, C Zhu, L Feng, F Torres, S Bollineni… - Transplant …, 2020 - Elsevier
Abstract Background Primary graft Dysfunction (PGD) results in significant mortality and
morbidity after lung transplantation (LT). The objective of this study was to evaluate if pre-
existing antibodies to self-antigens in sera of LT recipients are associated with PGD.
Methods The serum profiles of IgG and IgA autoantibodies were analyzed using a
customized proteomic microarray bearing 124 autoantigens. Autoantibodies were analyzed
using Mann-Whitney U test or Fisher exact test. The association of the autoantibodies with …
morbidity after lung transplantation (LT). The objective of this study was to evaluate if pre-
existing antibodies to self-antigens in sera of LT recipients are associated with PGD.
Methods The serum profiles of IgG and IgA autoantibodies were analyzed using a
customized proteomic microarray bearing 124 autoantigens. Autoantibodies were analyzed
using Mann-Whitney U test or Fisher exact test. The association of the autoantibodies with …