CXCL5 drives neutrophil recruitment in TH17-mediated GN
EM Disteldorf, CF Krebs, HJ Paust… - Journal of the …, 2015 - journals.lww.com
Neutrophil trafficking to sites of inflammation is essential for the defense against bacterial
and fungal infections, but also contributes to tissue damage in TH 17-mediated
autoimmunity. This process is regulated by chemokines, which often show an overlapping
expression pattern and function in pathogen-and autoimmune-induced inflammatory
reactions. Using a murine model of crescentic GN, we show that the pathogenic TH 17/IL-17
immune response induces chemokine (CXC motif) ligand 5 (CXCL5) expression in kidney …
and fungal infections, but also contributes to tissue damage in TH 17-mediated
autoimmunity. This process is regulated by chemokines, which often show an overlapping
expression pattern and function in pathogen-and autoimmune-induced inflammatory
reactions. Using a murine model of crescentic GN, we show that the pathogenic TH 17/IL-17
immune response induces chemokine (CXC motif) ligand 5 (CXCL5) expression in kidney …