Cell death in the pathogenesis of systemic lupus erythematosus and lupus nephritis
P Mistry, MJ Kaplan - Clinical Immunology, 2017 - Elsevier
Nephritis is one of the most severe complications of systemic lupus erythematosus (SLE).
One key characteristic of lupus nephritis (LN) is the deposition of immune complexes
containing nucleic acids and/or proteins binding to nucleic acids and autoantibodies
recognizing these molecules. A variety of cell death processes are implicated in the
generation and externalization of modified nuclear autoantigens and in the development of
LN. Among these processes, apoptosis, primary and secondary necrosis, NETosis …
One key characteristic of lupus nephritis (LN) is the deposition of immune complexes
containing nucleic acids and/or proteins binding to nucleic acids and autoantibodies
recognizing these molecules. A variety of cell death processes are implicated in the
generation and externalization of modified nuclear autoantigens and in the development of
LN. Among these processes, apoptosis, primary and secondary necrosis, NETosis …