GDF15 is a novel biomarker to evaluate efficacy of pyruvate therapy for mitochondrial diseases
Y Fujita, M Ito, T Kojima, S Yatsuga, Y Koga, M Tanaka - Mitochondrion, 2015 - Elsevier
Pyruvate therapy is a promising approach for the treatment of mitochondrial diseases. To
identify novel biomarkers for diagnosis and to evaluate therapeutic efficacy, we performed
microarray analysis of 2SD cybrid cells harboring a MELAS-causing mutation and control
cells treated with either lactate or pyruvate. We found that expression and secretion of
growth differentiation factor 15 (GDF15) were increased in 2SD cells treated with lactate and
that serum GDF15 levels were significantly higher in patients with mitochondrial diseases …
identify novel biomarkers for diagnosis and to evaluate therapeutic efficacy, we performed
microarray analysis of 2SD cybrid cells harboring a MELAS-causing mutation and control
cells treated with either lactate or pyruvate. We found that expression and secretion of
growth differentiation factor 15 (GDF15) were increased in 2SD cells treated with lactate and
that serum GDF15 levels were significantly higher in patients with mitochondrial diseases …