[HTML][HTML] Binding of anti-GRP78 autoantibodies to cell surface GRP78 increases tissue factor procoagulant activity via the release of calcium from endoplasmic …
AA Al-Hashimi, J Caldwell, M Gonzalez-Gronow… - Journal of biological …, 2010 - ASBMB
The increased risk of venous thromboembolism in cancer patients has been attributed to
enhanced tissue factor (TF) procoagulant activity (PCA) on the surface of cancer cells.
Recent studies have shown that TF PCA can be modulated by GRP78, an endoplasmic
reticulum (ER)-resident molecular chaperone. In this study, we investigated the role of cell
surface GRP78 in modulating TF PCA in several human cancer cell lines. Although both
GRP78 and TF are present on the cell surface of cancer cells, there was no evidence of a …
enhanced tissue factor (TF) procoagulant activity (PCA) on the surface of cancer cells.
Recent studies have shown that TF PCA can be modulated by GRP78, an endoplasmic
reticulum (ER)-resident molecular chaperone. In this study, we investigated the role of cell
surface GRP78 in modulating TF PCA in several human cancer cell lines. Although both
GRP78 and TF are present on the cell surface of cancer cells, there was no evidence of a …