The global epidemic of obesity has been accompanied by a rising burden of non-alcoholic
fatty liver disease (NAFLD), with manifestations ranging from simple steatosis to non-
alcoholic steatohepatitis, potentially developing into hepatocellular carcinoma. Although
much attention has focused on NAFLD, its pathogenesis remains largely obscure. The
hallmark of NAFLD is the hepatic accumulation of lipids, which subsequently leads to
cellular stress and hepatic injury, eventually resulting in chronic liver disease. Abnormal lipid …