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Viral interference induced by live attenuated virus vaccine (OPV) can prevent otitis media

E Seppälä, H Viskari, S Hoppu, H Honkanen… - Vaccine, 2011 - Elsevier
E Seppälä, H Viskari, S Hoppu, H Honkanen, H Huhtala, O Simell, J Ilonen, M Knip, H Hyöty
Vaccine, 2011•Elsevier
BACKGROUND: The goal of this study was to evaluate whether a live attenuated poliovirus
vaccine (OPV) has clinically relevant interfering effect with non-polio infections causing otitis
media in young children. METHODS: Open trial in which the intervention group (64 children)
received OPV at the age of 2, 3, 6 and 12months. The control group (250 children) received
IPV (inactivated polio vaccine) at the age of 6 and 12months. Clinical symptoms were
recorded by a questionnaire at the age of 3, 6, 12, 18 and 24months. RESULTS: Otitis media …
BACKGROUND
The goal of this study was to evaluate whether a live attenuated poliovirus vaccine (OPV) has clinically relevant interfering effect with non-polio infections causing otitis media in young children.
METHODS
Open trial in which the intervention group (64 children) received OPV at the age of 2, 3, 6 and 12months. The control group (250 children) received IPV (inactivated polio vaccine) at the age of 6 and 12months. Clinical symptoms were recorded by a questionnaire at the age of 3, 6, 12, 18 and 24months.
RESULTS
Otitis media episodes were less frequent in the OPV than in the control group. A significant difference was seen at the age of 6–18months (IRR=0.76 [95% CI 0.59–0.94], P=0.011) and was particularly clear among children, who attended daycare (IRR 0.37 [95% CI 0.19–0.71], P=0.003).
CONCLUSIONS
OPV provides some protection against otitis media. This effect may be mediated by viral interference with non-polio viruses.
Elsevier
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