Dorsolateral septum somatostatin interneurons gate mobility to calibrate context-specific behavioral fear responses

A Besnard, Y Gao, M TaeWoo Kim, H Twarkowski… - Nature …, 2019 - nature.com
A Besnard, Y Gao, M TaeWoo Kim, H Twarkowski, AK Reed, T Langberg, W Feng, X Xu
Nature neuroscience, 2019nature.com
Adaptive fear responses to external threats rely upon efficient relay of computations
underlying contextual encoding to subcortical circuits. Brain-wide analysis of highly
coactivated ensembles following contextual fear discrimination identified the dorsolateral
septum (DLS) as a relay of the dentate gyrus–CA3 circuit. Retrograde monosynaptic tracing
and electrophysiological whole-cell recordings demonstrated that DLS somatostatin-
expressing interneurons (SST-INs) receive direct CA3 inputs. Longitudinal in vivo calcium …
Abstract
Adaptive fear responses to external threats rely upon efficient relay of computations underlying contextual encoding to subcortical circuits. Brain-wide analysis of highly coactivated ensembles following contextual fear discrimination identified the dorsolateral septum (DLS) as a relay of the dentate gyrus–CA3 circuit. Retrograde monosynaptic tracing and electrophysiological whole-cell recordings demonstrated that DLS somatostatin-expressing interneurons (SST-INs) receive direct CA3 inputs. Longitudinal in vivo calcium imaging of DLS SST-INs in awake, behaving mice identified a stable population of footshock-responsive SST-INs during contextual conditioning whose activity tracked and predicted non-freezing epochs during subsequent recall in the training context but not in a similar, neutral context or open field. Optogenetic attenuation or stimulation of DLS SST-INs bidirectionally modulated conditioned fear responses and recruited proximal and distal subcortical targets. Together, these observations suggest a role for a potentially hard-wired DLS SST-IN subpopulation as arbiters of mobility that calibrate context-appropriate behavioral fear responses.
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