Pharmacologic rescue of impaired cognitive flexibility, social deficits, increased aggression, and seizure susceptibility in oxytocin receptor null mice: a …
M Sala, D Braida, D Lentini, M Busnelli, E Bulgheroni… - Biological …, 2011 - Elsevier
BACKGROUND: Oxytocin (OT) has been suggested as a treatment to improve social
behavior in autistic patients. Accordingly, the OT (Oxt−/−) and the OT receptor null mice
(Oxtr−/−) display autistic-like deficits in social behavior, increased aggression, and reduced
ultrasonic vocalization. METHODS: Oxtr−/− mice were characterized for general health,
sociability, social novelty, cognitive flexibility, aggression, and seizure susceptibility.
Because vasopressin (AVP) and OT cooperate in controlling social behavior, learning, and …
behavior in autistic patients. Accordingly, the OT (Oxt−/−) and the OT receptor null mice
(Oxtr−/−) display autistic-like deficits in social behavior, increased aggression, and reduced
ultrasonic vocalization. METHODS: Oxtr−/− mice were characterized for general health,
sociability, social novelty, cognitive flexibility, aggression, and seizure susceptibility.
Because vasopressin (AVP) and OT cooperate in controlling social behavior, learning, and …