[HTML][HTML] Down-regulation of the small conductance calcium-activated potassium channels in diabetic mouse atria
F Yi, TY Ling, T Lu, XL Wang, J Li, WC Claycomb… - Journal of Biological …, 2015 - ASBMB
The small conductance Ca 2+-activated K+(SK) channels have recently been found to be
expressed in the heart, and genome-wide association studies have shown that they are
implicated in atrial fibrillation. Diabetes mellitus is an independent risk factor of atrial
fibrillation, but the ionic mechanism underlying this relationship remains unclear. We
hypothesized that SK channel function is abnormal in diabetes mellitus, leading to altered
cardiac electrophysiology. We found that in streptozotocin-induced diabetic mice, the …
expressed in the heart, and genome-wide association studies have shown that they are
implicated in atrial fibrillation. Diabetes mellitus is an independent risk factor of atrial
fibrillation, but the ionic mechanism underlying this relationship remains unclear. We
hypothesized that SK channel function is abnormal in diabetes mellitus, leading to altered
cardiac electrophysiology. We found that in streptozotocin-induced diabetic mice, the …