Sodium‐glucose co‐transporter inhibitors, their role in type 1 diabetes treatment and a risk mitigation strategy for preventing diabetic ketoacidosis: the STOP DKA …

RM Goldenberg, JD Gilbert, IM Hramiak… - Diabetes, Obesity …, 2019 - Wiley Online Library
RM Goldenberg, JD Gilbert, IM Hramiak, VC Woo, B Zinman
Diabetes, Obesity and Metabolism, 2019Wiley Online Library
Recent phase 3 clinical trials have evaluated the impact of adding sodium‐glucose co‐
transporter (SGLT) inhibitors to the type 1 diabetes armamentarium. These trials studied
SGLT2 inhibitors (dapagliflozin and empagliflozin) and a dual SGLT1 and SGLT2 inhibitor
(sotagliflozin), and demonstrated that these oral non‐insulin antihyperglycaemic
medications are able not only to improve glycaemic control, but also to reduce body weight
and extend time in range without increasing rates of hypoglycaemia in type 1 diabetes …
Abstract
Recent phase 3 clinical trials have evaluated the impact of adding sodium‐glucose co‐transporter (SGLT) inhibitors to the type 1 diabetes armamentarium. These trials studied SGLT2 inhibitors (dapagliflozin and empagliflozin) and a dual SGLT1 and SGLT2 inhibitor (sotagliflozin), and demonstrated that these oral non‐insulin antihyperglycaemic medications are able not only to improve glycaemic control, but also to reduce body weight and extend time in range without increasing rates of hypoglycaemia in type 1 diabetes. Diabetic ketoacidosis (DKA) is a feature of type 1 diabetes and the risk is increased when SGLT inhibitors are used in type 1 diabetes. To minimize the risk of DKA and still gain the multiple benefits, we developed the “STOP DKA Protocol “, an easily accessible and practical tool, that provides a risk mitigation strategy for reducing DKA in patients with type 1 diabetes being treated with SGLT inhibitors.
Wiley Online Library