[HTML][HTML] Identification and characterization of a novel inositol polyphosphate 5-phosphatase
M Funaki, T Asano, T Ijuin, Y Mochizuki… - Journal of Biological …, 2000 - ASBMB
We have identified a cDNA encoding a novel inositol polyphosphate 5-phosphatase. It
contains two highly conserved catalytic motifs for 5-phosphatase, has a molecular mass of
51 kDa, and is ubiquitously expressed and especially abundant in skeletal muscle, heart,
and kidney. We designated this 5-phosphatase as SKIP (Skeletal muscle and Kidney
enrichedInositol Phosphatase). SKIP is a simple 5-phosphatase with no other motifs.
Baculovirus-expressed recombinant SKIP protein exhibited 5-phosphatase activities toward …
contains two highly conserved catalytic motifs for 5-phosphatase, has a molecular mass of
51 kDa, and is ubiquitously expressed and especially abundant in skeletal muscle, heart,
and kidney. We designated this 5-phosphatase as SKIP (Skeletal muscle and Kidney
enrichedInositol Phosphatase). SKIP is a simple 5-phosphatase with no other motifs.
Baculovirus-expressed recombinant SKIP protein exhibited 5-phosphatase activities toward …