Autophagy is a lysosome-dependent degradation process that is essential for maintaining
cellular homeostasis. In recent years, more studies have focused on the late stages of
autophagy. Our group discovered and studied the terminal step of autophagy, namely
autophagic lysosome reformation (ALR). ALR is the process that regenerates functional
lysosomes from autolysosomes, thus maintaining lysosome homeostasis. ALR involves
clathrin-mediated membrane budding from autolysosomes, elongation of membrane tubules …