Specific alterations in the performance of learning and memory tasks in models of chemoconvulsant-induced status epilepticus
Cognitive impairment is a common comorbidity in patients with Temporal Lobe Epilepsy
(TLE). These impairments, particularly deficits in learning and memory, can be recapitulated
in chemoconvulsant models of TLE. Here, we used two relatively low-stress behavioral
paradigms, the novel object recognition task (NOR) and a spatial variation, the novel
placement recognition task (NPR) to reveal deficits in short and long term memory, in both
kainic acid (KA) and pilocarpine (Pilo) treated animals. We found that both KA-and Pilo …
(TLE). These impairments, particularly deficits in learning and memory, can be recapitulated
in chemoconvulsant models of TLE. Here, we used two relatively low-stress behavioral
paradigms, the novel object recognition task (NOR) and a spatial variation, the novel
placement recognition task (NPR) to reveal deficits in short and long term memory, in both
kainic acid (KA) and pilocarpine (Pilo) treated animals. We found that both KA-and Pilo …