[HTML][HTML] Proteomic analysis of wild-type and mutant huntingtin-associated proteins in mouse brains identifies unique interactions and involvement in protein synthesis
Huntington disease is a neurodegenerative disorder caused by a CAG repeat amplification
in the gene huntingtin (HTT) that is reflected by a polyglutamine expansion in the Htt protein.
Nearly 20 years of research have uncovered roles for Htt in a wide range of cellular
processes, and many of these discoveries stemmed from the identification of Htt-interacting
proteins. However, no study has employed an impartial and comprehensive strategy to
identify proteins that differentially associate with full-length wild-type and mutant Htt in brain …
in the gene huntingtin (HTT) that is reflected by a polyglutamine expansion in the Htt protein.
Nearly 20 years of research have uncovered roles for Htt in a wide range of cellular
processes, and many of these discoveries stemmed from the identification of Htt-interacting
proteins. However, no study has employed an impartial and comprehensive strategy to
identify proteins that differentially associate with full-length wild-type and mutant Htt in brain …