The androgen receptor undergoes nuclear import in response to ligand, but the mechanism
by which it undergoes nuclear export is poorly understood. We developed a permeabilized
cell assay to characterize nuclear export of the androgen receptor in LNCaP prostate cancer
cells. We found that nuclear export of endogenous androgen receptor can be stimulated by
short double-stranded DNA oligonucleotides. This androgen receptor export pathway is
dependent on ATP hydrolysis and is enhanced by phosphatase inhibition with okadaic acid …