[HTML][HTML] Multiple structural and epigenetic defects in the human leukocyte antigen class I antigen presentation pathway in a recurrent metastatic melanoma following …
CC Chang, G Pirozzi, SH Wen, IH Chung… - Journal of Biological …, 2015 - ASBMB
Scant information is available about the molecular basis of multiple HLA class I antigen-
processing machinery defects in malignant cells, although this information contributes to our
understanding of the molecular immunoescape mechanisms utilized by tumor cells and may
suggest strategies to counteract them. In the present study we reveal a combination of IFN-γ-
irreversible structural and epigenetic defects in HLA class I antigen-processing machinery in
a recurrent melanoma metastasis after immunotherapy. These defects include loss of …
processing machinery defects in malignant cells, although this information contributes to our
understanding of the molecular immunoescape mechanisms utilized by tumor cells and may
suggest strategies to counteract them. In the present study we reveal a combination of IFN-γ-
irreversible structural and epigenetic defects in HLA class I antigen-processing machinery in
a recurrent melanoma metastasis after immunotherapy. These defects include loss of …