A positive look at double-negative thymocytes
R Ceredig, T Rolink - Nature Reviews Immunology, 2002 - nature.com
R Ceredig, T Rolink
Nature Reviews Immunology, 2002•nature.comIn some respects, our understanding of the cellular and molecular aspects of early T-cell
differentiation is lagging behind that of B cells. Papers describing gene-knockout and
reporter-transgenic mice in which thymocyte development is affected are often difficult to
interpret. Progress in this field will be hampered unless a more detailed phenotypic and
molecular analysis of progenitor thymocytes at the single-cell level is carried out.
differentiation is lagging behind that of B cells. Papers describing gene-knockout and
reporter-transgenic mice in which thymocyte development is affected are often difficult to
interpret. Progress in this field will be hampered unless a more detailed phenotypic and
molecular analysis of progenitor thymocytes at the single-cell level is carried out.
Abstract
In some respects, our understanding of the cellular and molecular aspects of early T-cell differentiation is lagging behind that of B cells. Papers describing gene-knockout and reporter-transgenic mice in which thymocyte development is affected are often difficult to interpret. Progress in this field will be hampered unless a more detailed phenotypic and molecular analysis of progenitor thymocytes at the single-cell level is carried out.
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