EMT transcription factors in cancer development re-evaluated: Beyond EMT and MET
S Goossens, N Vandamme, P Van Vlierberghe… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 2017•Elsevier
Reactivation of an embryonic epithelial-to-mesenchymal (EMT) program is commonly
accepted as a core component of carcinoma progression. Collectively, EMT and
transcription factors (EMT-TFs) of the ZEB, SNAIL and TWIST families are quoted in the
same breath for nearly 20 years. Recent work on these EMT-TFs has extended their scope,
and their typical definition as EMT-inducing factors has become out-of-date. New insights
have warranted a re-evaluation of these transcription factors and their pleiotropic functions …
accepted as a core component of carcinoma progression. Collectively, EMT and
transcription factors (EMT-TFs) of the ZEB, SNAIL and TWIST families are quoted in the
same breath for nearly 20 years. Recent work on these EMT-TFs has extended their scope,
and their typical definition as EMT-inducing factors has become out-of-date. New insights
have warranted a re-evaluation of these transcription factors and their pleiotropic functions …
Abstract
Reactivation of an embryonic epithelial-to-mesenchymal (EMT) program is commonly accepted as a core component of carcinoma progression. Collectively, EMT and transcription factors (EMT-TFs) of the ZEB, SNAIL and TWIST families are quoted in the same breath for nearly 20 years. Recent work on these EMT-TFs has extended their scope, and their typical definition as EMT-inducing factors has become out-of-date. New insights have warranted a re-evaluation of these transcription factors and their pleiotropic functions in physiological and pathological conditions, not solely limited to cell invasion and dissemination.
Elsevier