[HTML][HTML] Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome CRelease* 210
I Kuwabara, Y Kuwabara, RY Yang, M Schuler… - Journal of Biological …, 2002 - ASBMB
Galectin-7 is normally expressed in all types of stratified epithelia, but is significantly down-
regulated in squamous cell carcinomas. This protein was recently found to be highly
inducible by p53 in a colon carcinoma cell line, DLD-1, and designated as PIG1 (for p53-
inducedgene 1). We studied transfectants of HeLa and DLD-1 cells ectopically expressing
this protein and found that they were more susceptible to apoptosis than control
transfectants. This was observed in apoptosis induced by mechanistically distinct stimuli …
regulated in squamous cell carcinomas. This protein was recently found to be highly
inducible by p53 in a colon carcinoma cell line, DLD-1, and designated as PIG1 (for p53-
inducedgene 1). We studied transfectants of HeLa and DLD-1 cells ectopically expressing
this protein and found that they were more susceptible to apoptosis than control
transfectants. This was observed in apoptosis induced by mechanistically distinct stimuli …