Dysregulation of miRNA146a versus IRAK1 induces IL-17 persistence in the psoriatic skin lesions
P Xia, X Fang, Z Zhang, Q Huang, K Yan, K Kang… - Immunology …, 2012 - Elsevier
Psoriasis is a common chronic inflammatory skin disorder with dysregulation of miRNAs.
The expression pattern of miR-146a and target gene IRAK1 in lesions and PBMCs of plaque
psoriasis remains unclear. In our study, we found the expression of miR-146a was up-
regulated both in lesions and PBMCs of psoriatic patients, and positively correlated with IL-
17 expression, whereas the target gene IRAK1 expression was expressed differentially in
lesions and peripheral blood. Inability of miR-146a inhibiting target gene IRAK1 may …
The expression pattern of miR-146a and target gene IRAK1 in lesions and PBMCs of plaque
psoriasis remains unclear. In our study, we found the expression of miR-146a was up-
regulated both in lesions and PBMCs of psoriatic patients, and positively correlated with IL-
17 expression, whereas the target gene IRAK1 expression was expressed differentially in
lesions and peripheral blood. Inability of miR-146a inhibiting target gene IRAK1 may …