Importance Performing DNA genetic testing (DGT) for hereditary cancer genes is now a well-
accepted clinical practice; however, the interpretation of DNA variation remains a challenge
for laboratories and clinicians. Adding RNA genetic testing (RGT) enhances DGT by
clarifying the clinical actionability of hereditary cancer gene variants, thus improving
clinicians' ability to accurately apply strategies for cancer risk reduction and treatment.
Objective To evaluate whether RGT is associated with improvement in the diagnostic …