[HTML][HTML] Adenovirus E4 gene promotes selective endothelial cell survival and angiogenesis via activation of the vascular endothelial-cadherin/Akt signaling pathway
F Zhang, J Cheng, NR Hackett, G Lam, K Shido… - Journal of Biological …, 2004 - ASBMB
The early 4 region (E4) of the adenoviral vectors (AdE4+) prolongs human endothelial cell
(EC) survival and alters the angiogenic response, although the mechanisms for the EC-
specific, AdE4+-mediated effects remain unknown. We hypothesized that AdE4+ modulates
EC survival through activation of the vascular endothelial (VE)-cadherin/Akt pathway. Here,
we showed that AdE4+, but not AdE4-vectors, selectively stimulated phosphorylation of both
Akt at Ser 473 and Src kinase in ECs. The phosphatidylinositol 3-kinase (PI3K) inhibitors …
(EC) survival and alters the angiogenic response, although the mechanisms for the EC-
specific, AdE4+-mediated effects remain unknown. We hypothesized that AdE4+ modulates
EC survival through activation of the vascular endothelial (VE)-cadherin/Akt pathway. Here,
we showed that AdE4+, but not AdE4-vectors, selectively stimulated phosphorylation of both
Akt at Ser 473 and Src kinase in ECs. The phosphatidylinositol 3-kinase (PI3K) inhibitors …